Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples
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چکیده
منابع مشابه
Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples.
PURPOSE Epidermal growth factor receptor variant III (EGFRvIII) is an oncogenic, constitutively active mutant form of the EGFR that is commonly expressed in glioblastoma and is also detected in a number of epithelial cancers. EGFRvIII presents a unique antigenic target for anti-EGFRvIII vaccines and it has been shown to modulate response to EGFR kinase inhibitor therapy. Thus, detection in clin...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2008
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-07-1966